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Doctor Discussion Guide
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Discover the first and only second-generation intravenous (IV) antihistamine

QUZYTTIR is an FDA-approved prescription medicine for the treatment of short-term hives (known as acute urticaria) in adults and children 6 months of age and older.

QUZYTTIR is not recommended in children younger than 6 years old with kidney or liver problems.

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How QUZYTTIR was studied

In a clinical study of 262 adult patients presenting to emergency rooms or urgent care centers with short-term hives, 127 were given QUZYTTIR and 135 were given IV diphenhydramine to treat their hives. Patients rated their level of itch (rated 0-3, where 3 is most itchy) from hives before treatment and 2 hours after treatment with either QUZYTTIR or IV diphenhydramine.

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QUZYTTIR worked like IV diphenhydramine at reducing itch from hives due to allergic reactions

Patients were also followed to see if they needed to return to the emergency room or clinic due to their hives coming back

2X fewer return visits

More than twice as many IV diphenhydramine patients returned to their center of care after discharge compared with those who received QUZYTTIR

6%

of QUZYTTIR patients had to return

14%

of IV diphenhydramine patients had to return

Patients also rated their level of drowsiness with either QUZYTTIR or IV diphenhydramine:

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Less drowsiness

QUZYTTIR patients were not as tired during and after treatment compared to those who received IV diphenhydramine

How QUZYTTIR works differently:

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Starts fast

Starts working in less than 4 minutes

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Lasts long

Lasts for 24 hours for consistent symptom relief

Taking QUZYTTIR

QUZYTTIR is a single-use vial that must be administered intravenously by a medical professional. It is preservative-free and does not require refrigeration.

The recommended dosage regimen is once every 24 hours as needed for symptom relief. The recommended dosage depends on your age and doctor’s judgement.

You may receive QUZYTTIR in your doctor’s office, at your infusion center, in urgent care clinics, or while at the hospital. If needed, some people may receive at-home treatment by a medical professional.

Vial of QUZYTTIR

QUZYTTIR has been proven safe in children and adults, including:

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6 months to 17 years

Children with kidney or liver problems should not take QUZYTTIR.

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65 years and older

In clinical trials with QUZYTTIR, 18 patients were 65 years and older, and 6 patients were 75 years and older. There were no major differences in safety between older and younger patients, but more side effects might be seen in older adults.

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Possible side effects of QUZYTTIR

In the clinical trial, the following were the most common side effects with QUZYTTIR, which occurred in less than 1% of patients:

  • a change in sense of taste
  • headache
  • a tingling sensation
  • feeling faint
  • indigestion
  • feeling hot
  • excessive sweating

QUZYTTIR may cause sleepiness. Use caution when driving a car or operating machinery. Avoid alcohol or taking certain other medicines with QUZYTTIR, as this may raise your risk of problems with alertness or thinking.

This is your Q: Ask your doctor if QUZYTTIR is right for you

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Patient Brochure

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Role of Antihistamines

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IMPORTANT SAFETY INFORMATION
  • You should not receive QUZYTTIR if you are allergic to any of its ingredients or if you are allergic to other medicines that contain levocetirizine or hydroxyzine.
  • QUZYTTIR may cause sleepiness. Be careful when driving a car or operating potentially dangerous machinery. Avoid alcohol or taking certain other medicines with QUZYTTIR, as this may raise your risk of having problems with alertness or thinking. Tell the healthcare provider treating you about all the medicines you are taking, including prescription or over-the-counter medicines, vitamins, or herbal supplements.
  • QUZYTTIR was not studied in pregnant or nursing women. Tell your healthcare provider if you are pregnant, plan to become pregnant, or are breastfeeding.
  • The most common side effects (which occurred in <1% of patients) are: a change in sense of taste, headache, a tingling sensation, feeling faint, indigestion, feeling hot, and excessive sweating.
  • The most common side effects observed in studies of an oral form of the active ingredient in QUZYTTIR taken by adults for a prolonged amount of time were sleepiness, tiredness, dry mouth, sore throat, and dizziness. In similar studies with children, the most common side effects were headache, sore throat, abdominal pain, sleepiness, diarrhea, nosebleed, bronchial spasm, nausea, and vomiting.
  • Call your healthcare provider about any side effects that you may experience.

You are encouraged to report negative side effects of prescription drugs to the FDA. To report SUSPECTED ADVERSE REACTIONS, contact the FDA at 1-800-FDA-1088 or www.FDA.gov/medwatch. You may also contact TerSera Therapeutics at 1-844-334-4035 or medicalinformation@tersera.com.

Please see accompanying Full Prescribing Information.

What is QUZYTTIR?

QUZYTTIR is an FDA-approved prescription medicine for the treatment of short-term hives (known as acute urticaria) in adults and children 6 months of age and older.

QUZYTTIR is not recommended in children younger than 6 years old with kidney or liver problems.

You are encouraged to report negative side effects of prescription drugs to the FDA. To report SUSPECTED ADVERSE REACTIONS, contact the FDA at 1-800-FDA-1088 or www.FDA.gov/medwatch. You may also contact TerSera Therapeutics at 1-844-334-4035 or medicalinformation@tersera.com.

Please see accompanying Full Prescribing Information.